Hydrabio Gel-Cream can be used once or twice a day, seven days a week. Start by cleansing your face and neck with one of the cleansers from our Hydrabio line. Apply Hydrabio Tonic Lotion or Hydrabio Serum if needed, then apply Hydrabio Gel-Cream. When used as a night cream, Hydrabio Cream can be combined with Hydrabio Gel-Cream of the latter is used as a day treatment.